CONNECTOR is a webserver that predicts propensity of putative drug-protein interactions based on similarity between the input drug structure, drug profile, and/or protein sequence and the experimental drug-protein interactions that are included in the internal database. This webserver facilitates prediction for any combination of inputs including any individual input (drug structure, drug profile, and protein sequence), any pair of inputs, and all three inputs.
The internal database of CONNECTOR integrates drug-protein interactions that were collected from Therapeutic Target Database, IUPHAR/BPS Guide to Pharmacology database and Drug2Gene that combines data from CGDCP, ChEBI, ChEMBL, CTD, DrugBank, HGNC, Ligand Expo, MICAD, NCBI Gene, Pathway Commons DB, PDBsum, PDSP Ki, PharmGKB, Pubchem Bioassay, PubChem Compound, PubChem Substance, and UniProt.
The current version of the internal database includes 449 drugs, 1469 protein targets, and 34456 drug-protein interactions
Please follow the three steps below to make predictions.
The benchmark database
Upon the usage the users are requested to use the following citation: