Cyclic proteins (CPs) have circular chains with a continuous cycle of peptide bonds. Their unique structural traits give them greater stability, better receptor selectively, and improved pharmacodynamic properties when compared to their acyclic counterparts, making them promising targets for pharmaceutical/therapeutic applications. This website provides access to the high-throughput sequence-based predictor of CPs, called CyPred, and putative CPs predicted from Archaea, Bacterial, and Eukaryotic proteomes.
CyPred is available as standalone application! (download: CyPred.zip (3.2 MB)). The package includes README.txt file which explains how to install and use the software. CyPred should execute on any operating system where JAVA (version 6 or higher) is installed.
Upon the usage the users are requested to use the following citation:
Each of the abovementioned files contains a file header that explains the format of the data in a given file.
CyPred accepts either single or multiple protein sequences and the input is limited to 75 000 protein sequences at the time. The user should submit the protein sequence(s) in FASTA format.
The format of the input file is as follows (example for incomplete proteome of Violaceae):
We acknowledge, with thanks, that the following software was used as a part of this server: