Multilayered Fusion-based Disorder predictor v. 2.00 (MFDp2)

MFDp2 combines per-residue disorder probabilities predicted by MFDp with per-sequence disorder content predicted by DisCon, and applies novel post-processing filters to provide disorder predictions with improved predictive quality. It outputs optimized per-residue disorder probability profiles, per-sequence disorder content, list (with analysis) of disordered segments, and several profiles that help in the interpretation of the results. The results are available online in graphical format and can be also downloaded in text-based (parsable) format.

Note: Result page enables the user to download the raw results from MFDp and DisCon as .csv or .fasta file if needed for comparison with other methods.

Please follow the three steps below to make predictions:

1. Enter protein sequence(s)

Server accepts up to 100 (FASTA formated) protein sequences.
Either upload a file:
or enter each protein in a new line in the following text field:

2. Provide your e-mail address (recommended):

Please provide your e-mail address to be notified when results are ready.

3. Predict:

HINT: The symbols indicate availability of (additional) explanations. Clicking opens a new window with help and hints related to the selected section/task.


Upon the usage the users are requested to use the following citations:

Additional materials


We acknowledge with thanks the following software used as a part of this server: