DisoRDPbind predicts the RNA-, DNA-, and protein-binding residues located in the intrinsically disordered regions. DisoRDPbind is implemented using a runtime-efficient multi-layered design that utilizes information extracted from physiochemical properties of amino acids, sequence complexity, putative secondary structure and disorder, and sequence alignment.
Upon the usage the users are requested to use the following citation:
The annotations are encoded as follows: "1" denotes residues annotated with the particular type of binding, "0" denotes residues with annotations that include other types of disordered or ordered residues, and "x" denotes the residues that lack annotations.
DisoRDPbind accepts either single or multiple protein sequences and the input is limited to 5000 protein sequences at the time. The user should submit the protein sequence(s) in FASTA format.
The format of the input file is as follows (Here is an example of input file where DisoRDPbind takes approximately 5 minutes to predict 500 proteins with average size of 300 AAs.):
We acknowledge with thanks the following software used as a part of this server: